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目的对高危型人乳头瘤病毒(HPV)感染检测及宫颈病变影响因素进行分析和探讨。方法 120例高危型人乳头瘤阳性患者作为研究对象,对患者进行阴道镜病理活检和液基薄层细胞学(TCT)检查,患者病毒负荷和年龄(RLU/CO)为自变量,宫颈病变程度为应变量,进行多元性回归分析,观察其相关性。结果患者宫颈病变程度的加重,明显会升高TCT阳性率。相对于宫颈炎和尖锐湿疣患者的TCT阳性率明显高于宫颈癌组和宫颈上皮内瘤变(CIN)组,差异具有统计学意义(P<0.05);年龄对宫颈病变的影响强度约为病毒负荷的1/2。结论高危型人乳头瘤病毒感染患者发生宫颈病变与年龄和病毒负荷因素密切相关,如患者检测未HC2阳性,即使应用TCT检查,检查结果为阴性,也必须对患者进行阴道镜检查。
Objective To analyze high risk human papillomavirus (HPV) infection and influencing factors of cervical lesions. Methods A total of 120 high risk human papilloma positive patients were included in this study. Colposcopy biopsy and liquid based cytology (TCT) were performed. The patients’ viral load and age (RLU / CO) were independent variables. The severity of cervical lesions For the variables, multiple regression analysis to observe its relevance. Results The severity of cervical lesions in patients with significantly increased TCT positive rate. The positive rate of TCT in patients with cervicitis and condyloma acuminata was significantly higher than that in cervical cancer and cervical intraepithelial neoplasia (CIN) (P <0.05). The effect of age on cervical lesions was about virus 1/2 of load Conclusions Cervical lesions in patients with high-risk human papillomavirus infection are closely related to age and viral load. If the patients are not detected positive for HC2, the results of colposcopy should be negative even if TCT is used. Colposcopy should also be performed on the patients.