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阿托伐他汀是新一代HMG-CoA还原酶抑制剂,能显著降低低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)及升高高密度脂蛋白胆固醇(HDL-C),药效明确,药物相互作用少,见效快,持续时间长,安全性和耐受性良好。随着其作为降脂药在临床的广泛使用,国内外学者对其非降脂作用及其机理进行了深入研究。本文就阿托伐他汀的非降脂作用进行综述。
Atorvastatin is a new generation of HMG-CoA reductase inhibitors, can significantly reduce the low density lipoprotein cholesterol (LDL-C), triglycerides (TG) and elevated high-density lipoprotein cholesterol (HDL-C) Effective, less drug interactions, quick, long duration, good safety and tolerability. With its widespread use as a lipid-lowering drug in the clinic, scholars at home and abroad have conducted in-depth studies on its non-lipid-lowering effects and its mechanism. This article reviews atorvastatin’s non-lipid-lowering effects.