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目的探讨十二指肠间质瘤的临床特点、诊断手段及治疗方法。方法回顾性分析我院2003年1月～2010年1月收治的16例十二指肠间质瘤的临床资料。结果本组患者以上消化道出血、腹部包块及上腹隐痛不适为常见症状,发病部位以降部和球部多见,分别经内镜、上消化道钡餐及上腹CT或MRI检查诊断本病。免疫组化检测示:CD117阳性15例,CD34阳性10例,S-100阳性4例,Actin阳性5例。所有患者均行手术切除肿瘤,预后良好。结论十二指肠间质瘤临床表现无特异性,合理选择内镜及影像学检查可以提高检出率。组织病理学及免疫组化检查是确诊手段。早期根治性手术是首选的治疗方法。
Objective To investigate the clinical features, diagnostic methods and treatment of duodenal stromal tumors. Methods The clinical data of 16 cases of duodenal stromal tumors admitted to our hospital from January 2003 to January 2010 were retrospectively analyzed. Results This group of patients with upper gastrointestinal bleeding, abdominal mass and upper abdominal pain discomfort are common symptoms, the incidence of parts to lower part and the ball more common, respectively, by endoscopy, upper gastrointestinal barium meal and upper abdominal CT or MRI diagnosis of the disease diagnosis . Immunohistochemistry showed that there were 15 positive CD117, 10 positive CD34, 4 positive S-100 and 5 positive Actin. All patients underwent surgical resection of the tumor with a good prognosis. Conclusion The clinical manifestations of duodenal stromal tumors are non-specific. Reasonable choice of endoscopy and imaging can improve the detection rate. Histopathology and immunohistochemistry are diagnostic tools. Early radical surgery is the preferred method of treatment.