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目的:探讨血清CRP、cTnI联合检测在急性心肌梗死诊断中的应用价值。方法:选取笔者所在医院收治的80例急性心肌梗死患者,根据发病时间将其分为两组,各40例。组1发病时间<4 h患者;组2发病时间4~8 h。另选40例健康者为对照,设为组3。采用化学发光法及免疫透射比浊法测定各组研究对象血清CRP及cTnI浓度。结果:三组间CRP浓度比较差异均有统计学意义(P<0.05);组1与组2的cTnI浓度比较具有明显差异,组2与组3的cTnI浓度比较也具有明显差异,两组比较差异均具有统计学意义(P<0.05)。但组1与组3的cTnI浓度比较差异无统计学意义(P>0.05)。组1与组2在CRP与cTnI联合检测确诊率均达到100%。结论:联合检测血清CRP、cTnI提高了检测的灵敏性与特异性,能有效提高急性心肌梗死的检出率及缩短检出时间,值得临床推广应用。
Objective: To investigate the value of combined detection of serum CRP and cTnI in the diagnosis of acute myocardial infarction. Methods: Eighty patients with acute myocardial infarction who were admitted to our hospital were selected and divided into two groups according to the time of onset: 40 cases each. Group 1 onset time <4 h patients; group 2 onset time 4 ~ 8 h. Another 40 healthy controls were selected as group 3. The concentrations of CRP and cTnI in serum of each group were determined by chemiluminescence and immunoturbidimetry. Results: There was significant difference in CRP concentrations between the three groups (P <0.05). The cTnI concentrations in group 1 and group 2 were significantly different, while the cTnI concentrations in group 2 and group 3 were also significantly different The differences were statistically significant (P <0.05). However, there was no significant difference in cTnI concentrations between group 1 and group 3 (P> 0.05). Group 1 and group 2 in CRP and cTnI joint detection of detection rate of 100%. Conclusion: Combined detection of serum CRP and cTnI can improve the sensitivity and specificity of detection, and can effectively improve the detection rate and shorten the detection time of acute myocardial infarction, which is worthy of clinical application.