[目的 ]测定消瘾剂 3个月经口染毒的毒性。 [方法 ]连续3个月经口给予“消瘾剂” ,每天 80、40、2 0g/kg剂量 ,对SD大鼠作一般状况、神经系统、血液生化和病理学检查。 [结果 ]在染毒期间出现流涎、体毛蓬松、体消瘦、精神萎靡及体重增长缓慢等 ,上述改变呈明显的剂量 反应关系。并存在明显的性别之差 ,雄性大鼠反应明显重于雌性大鼠 ,但停药后即逐渐消失。在整个试验期间未引起动物死亡。 3个剂量组对WBC、RBC、PLT、HGB等 12项血液学指标的AST、ALT、ALP、BUN、肌酐等 10项生化学指标均无明显影响 ,母鼠的测定值均属正常值范围 ;对部分脏器 (肝、肾、肾上腺、脾、胸腺、睾丸、前列腺、脑等 )、眼球外观及尿液色泽呈蓝灰色 (与消瘾剂稀释后颜色相似 ) ,色泽深浅呈剂量 反应关系。并在停药后逐渐消退 ,这可能与药液吸收有关。给药一个半月 (给药期间 )、停药次日、给药 3个月和恢复期结束 (停药一个月 )剖检 ,各剂量组对大鼠心、肝、脾、肺、肾、脑等脏器组织经大体和病理组织学检查 ,均未出现肉眼和镜下可见的病理形态学改变。 [结论 ]本试验结果显示 ,SD大鼠连续经口给予相当于人临床拟用剂量 80倍的消瘾剂 ,仅显示轻微的可逆性反应 ,未见明显的中毒表现。“消瘾剂”是一种毒性较低的中药戒毒药 [Objective] To determine the toxicity of oral detoxification agent 3 months after oral administration. [Method] The “de-addictive agent” was administered orally for 3 consecutive months and the daily dose of 80, 40 and 20 g / kg was given. The general condition, nervous system, blood biochemistry and pathology of SD rats were examined. [Results] There was a dose-response relationship between salivation, fluffy body, weight loss, sluggishness and slow weight gain during the exposure. And there is a clear gender difference, the male rat response was significantly heavier than female rats, but gradually disappear after withdrawal. No animal deaths occurred throughout the trial. The three dose groups had no significant effect on the ten biochemical indexes such as AST, ALT, ALP, BUN and creatinine of 12 hematological indexes such as WBC, RBC, PLT and HGB. The measured values ​​of the three groups were within the normal range. Some organs (liver, kidney, adrenal gland, spleen, thymus, testis, prostate, brain, etc.), the appearance of the eye and the urine color was blue-gray color (with anti-addictive diluted color similar), color depth was dose-response relationship. And gradually subsided after withdrawal, which may be related to liquid absorption. One month and a half after administration (administration period), the next day after drug withdrawal, the administration for 3 months and the end of convalescence (withdrawal for one month) Other organs such as gross and histopathological examination showed no macroscopic and microscopic pathological changes. [Conclusion] The results of this experiment showed that SD rats were given continuous oral administration equivalent to 80 times the dose of the human clinical trial, showing only mild reversible reaction and no obvious toxicosis. “Additives” is a less toxic traditional Chinese medicine drug