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目的探索硫酸镁和硝苯地平联合用于治疗妊娠高血压的效果。方法 168例妊娠高血压患者,按随机数表法将患者分为观察组和对照组,各84例。对照组患者给予硫酸镁治疗,观察组患者给予硫酸镁联合硝苯地平治疗,比较分析两组患者的治疗效果、血压及不良反应情况。结果观察组患者的治疗总有效率为97.62%,高于对照组的89.29%,差异有统计学意义(P<0.05)。治疗前,观察组患者的收缩压和舒张压与对照组比较差异无统计学意义(P>0.05);治疗1个月后,观察组患者的收缩压和舒张压均低于对照组,差异有统计学意义(P<0.05)。观察组患者治疗期间的不良反应发生率为5.95%,对照组患者的不良反应发生率为15.48%,比较差异有统计学意义(P<0.05)。结论妊娠高血压患者采用硫酸镁联合硝苯地平治疗效果确切,有助于促进患者血压水平趋于平稳,降低尿蛋白水平,且用药安全性高,值得在临床治疗中推广应用。
Objective To explore the effect of combination of magnesium sulfate and nifedipine in the treatment of pregnancy-induced hypertension. Methods A total of 168 cases of pregnancy-induced hypertension were divided into observation group and control group according to random number table method, each of 84 cases. Patients in the control group were treated with magnesium sulfate. Patients in the observation group were treated with magnesium sulfate and nifedipine. The therapeutic effects, blood pressure and adverse reactions of the two groups were compared. Results The total effective rate of observation group was 97.62%, which was higher than that of control group (89.29%), the difference was statistically significant (P <0.05). Before treatment, systolic blood pressure and diastolic blood pressure in the observation group were not significantly different from those in the control group (P> 0.05). After 1 month of treatment, the systolic and diastolic blood pressures of the observation group were lower than those of the control group Statistical significance (P <0.05). The incidence of adverse reactions in the observation group was 5.95%, while that in the control group was 15.48%. The difference was statistically significant (P <0.05). Conclusion Pregnancy-induced hypertension in patients with magnesium sulfate combined with nifedipine treatment effect is exact, will help to promote blood pressure levels in patients tend to be stable, lower urinary protein levels, and the drug is safe, it is worth in the clinical treatment of the promotion and application.