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目的探讨奥美拉唑持续静脉滴注治疗老年急性非静脉曲张性上消化道出血的疗效。方法 168例老年急性非静脉曲张性上消化道出血患者,随机分成研究组和对照组,各84例。研究组应用奥美拉唑(洛赛克)静脉滴注治疗,对照组应用法莫替丁静脉滴注治疗。比较两组患者止血效果。结果研究组患者止血显效38例、占45.2%,有效34例、占40.5%,无效12例、占14.3%,总有效率为85.7%;对照组患者止血显效8例、占9.5%,有效46例、占54.8%,无效30例、占35.7%,总有效率为64.3%。研究组患者止血显效率、总有效率均高于对照组,差异具有统计学意义(P<0.05)。结论奥美拉唑持续静脉滴注治疗老年急性非静脉曲张性上消化道出血疗效显著,且明显优于法莫替丁静脉滴注治疗的效果。
Objective To investigate the effect of continuous intravenous infusion of omeprazole in the treatment of acute non-variceal upper gastrointestinal bleeding in the elderly. Methods 168 cases of elderly patients with acute non-variceal upper gastrointestinal bleeding were randomly divided into study group and control group, 84 cases each. Study group omeprazole (Losec) intravenous infusion, the control group with famotidine intravenous infusion. Hemostatic effect was compared between two groups. Results In the study group, hemostasis was effective in 38 cases (45.2%), effective in 34 cases (40.5%), ineffective in 12 cases (14.3%) and total effective rate (85.7%). Cases, accounting for 54.8%, ineffective in 30 cases, accounting for 35.7%, the total effective rate was 64.3%. The effective rate of hemostasis and total effective rate of study group were higher than that of control group, the difference was statistically significant (P <0.05). Conclusion Omeprazole sustained intravenous infusion of the treatment of acute non-variceal upper gastrointestinal bleeding in elderly significant effect, and significantly better than the efficacy of famotidine intravenous infusion.