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背景:补肾中药为骨伤科常用药,但对不同有效成分用于骨愈合的比较研究尚缺乏。目的:观察不同补肾中药有效成分对骨损伤大鼠骨愈合及血液流变学的影响。方法:建立大鼠股骨干骨折模型并分别用提取的骨碎补总黄酮、淫羊藿总黄酮、菟丝子总黄酮、柚皮甙、槲皮素,以及橙皮甙对造模大鼠进行灌胃治疗。21d后取血及骨标本,检测大鼠骨愈合程度和血液流变学指标。结果与结论:不同补肾中药有效成分均对骨愈合有益,且骨碎补总黄酮、淫羊藿总黄酮效果优于其他4种药物。骨碎补总黄酮和淫羊藿总黄酮可有效抑制低剪切速下大鼠的血液黏度,降低红细胞聚集指数及血小板聚集性和黏附性(P<0.05),但对红细胞变形性无显著作用。说明补肾中药有效成分可促进骨损伤的愈合,且对血液流变学有一定作用,以骨碎补总黄酮效果最佳。
BACKGROUND: Bushen Chinese medicine is commonly used in orthopedics, but comparative studies on different effective components for bone healing are still lacking. OBJECTIVE: To observe the effect of different TCM ingredients of tonifying kidney on bone healing and hemorheology in rats with bone injury. Methods: The model of femoral shaft fracture was established in rats. The total flavonoids of Rhizoma Drynariae, Epimedium total flavone, Dodder total flavonoids, naringin, quercetin, treatment. After 21 days, blood and bone samples were taken to detect the degree of bone healing and hemorheology in rats. RESULTS AND CONCLUSION: The active ingredients of different kidney invigorating traditional Chinese medicines are beneficial to bone healing. The total flavonoids of Rhizoma Drynariae and Epimedium are better than the other four drugs. Total flavonoids of Rhizoma Drynariae and total flavonoids of Epimedium can effectively inhibit the blood viscosity, reduce the aggregation index of erythrocytes, platelet aggregation and adhesion (P <0.05), but have no significant effect on erythrocyte deformability . Indicating that the active ingredients of traditional Chinese medicine can promote the healing of bone injury, and have a certain effect on hemorheology, to the best effect of total flavonoids drynaria.