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目的探讨P16蛋白在人血管瘤发生、发展及消退过程中的表达状况及其生物学意义。方法 采用免疫组织化学方法(SABC法)检测人血管瘤增生期、消退期及正常组织中P16蛋白的表达水平。结果增生期血管瘤内皮细胞P16蛋白的表达水平低于消退期,消退期血管瘤内皮细胞P16蛋白的表达水平低于正常组织,各组之间差异均有显著性(P<0.05)。结论①P16蛋白的表达水平与血管瘤的发生、发展及消退有关。②P16蛋白通过抑制血管瘤内皮细胞的增殖和血管生成在血管瘤的消退过程中起重要作用。
Objective To investigate the expression of P16 protein in human hemangiomas during their development, development and regression and their biological significance. Methods Immunohistochemistry (SABC method) was used to detect the expression of P16 protein in proliferating, retiring and normal tissues of human hemangioma. Results The expression of P16 protein in proliferating hemangioma endothelial cells was lower than that in regression. The expression of P16 protein in endothelium of hemangiomas was lower than that in normal tissues in remission stage (P <0.05). Conclusion ① The expression of P16 protein is related to the occurrence, development and regression of hemangiomas. ② P16 protein plays an important role in the regression of hemangiomas by inhibiting the proliferation and angiogenesis of the hemangioma endothelial cells.