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更深入和全面地评价巴戟天水提物的抗抑郁作用。方法 :采用大鼠低速率差式强化程序 (DRL 72s)和小鼠强迫性游泳法。结果 :在大鼠DRL 72s模型上 ,巴戟天水提物 50mg/kg与抗抑郁剂地昔帕明 5mg/kg的作用一致 ,均显著增加大鼠DRL 72s的强化数 ,减少反应数和降低效应比率。在小鼠强迫性游泳模型上 ,巴戟天水提物 50mg/kg与地昔帕明 2 0mg/kg和阿米替林2 0mg/kg的作用类似 ,明显缩短小鼠的不动时间 ,巴戟天水提物 2 5mg/kg也具有缩短小鼠不动时间的趋势。同时 ,巴戟天水提物在有效缩短小鼠不动时间的剂量 ( 2 5～ 50mg/kg)时不影响小鼠自发活动性。结论 :进一步表明巴戟天水提物具有抗抑郁作用。
A more in-depth and comprehensive evaluation of the anti-depressant effect of Morinda officinalis extract. METHODS: Rats with low-rate differential enhancement (DRL 72s) and compulsive swimming in mice were used. RESULTS: On the rat DRL 72s model, the effect of Radix Morinda officinalis extract 50 mg/kg was consistent with the effect of antidepressant desipramine 5 mg/kg, both of which significantly increased the number of rat DRL 72s enhancement, reduced the number of responses and reduced the effect. ratio. In mice forced swimming model, the effect of Morinda officinalis extract 50 mg/kg was similar to the effect of desipramine 20 mg/kg and amitriptyline 20 mg/kg, which significantly shortened the immobility time of mice. Tianshui extract 25mg/kg also has the tendency to shorten the immobility time of mice. At the same time, Morinda officinalis extract did not affect the spontaneous activity of mice when it was effective in shortening the dose (25-50 mg/kg) of immobility time. Conclusion : It is further shown that the extract of Morinda officinalis has antidepressant effect.