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感染后肠易激综合征(PI-IBS)是肠易激综合征(IBS)的常见临床类型。内脏高敏感是PI-IBS的核心机制之一,其形成可能是源于胃肠道传入神经通路的敏感化和抑制性调控内脏痛反应的神经通路功能减退。肠黏膜肥大细胞可通过其脱颗粒产物如5-羟色胺(5-HT)等参与调节内脏高敏感,目前相关制剂已用于IBS的治疗,但疗效尚不确定。因此,深入了解肠黏膜肥大细胞功能改变在PI-IBS内脏高敏感发生机制中的作用,将为阐明PI-IBS的病理生理机制及其临床治疗提供新的思路。
Infectious irritable bowel syndrome (PI-IBS) is a common clinical type of irritable bowel syndrome (IBS). Visceral hypersensitivity is one of the core mechanisms of PI-IBS, and its formation may be due to the sensitization of the gastrointestinal afferent nerve pathway and the inhibition of neural pathways that inhibit the visceral pain response. Intestinal mucosal mast cells can be involved in the regulation of visceral hypersensitivity through its degranulation products such as 5-HT (5-HT). At present, the relevant preparations have been used in the treatment of IBS, but the efficacy is still uncertain. Therefore, understanding the role of intestinal mucosal mast cell function changes in the visceral hypersensitivity mechanism of PI-IBS will provide new ideas for elucidating the pathophysiological mechanism of PI-IBS and its clinical treatment.