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目的:评价Thinprep液基细胞学在宫颈癌筛查的准确性。方法:1881例受检者同时做宫颈常规脱落细胞涂片巴氏染色、液基标本采集和阴道镜活检,细胞学诊断采用TBS分级系统,阳性诊断包括意义不明的不典型鳞状细胞病变,所有检查均双盲进行。结果:Thinprep液基细胞学检出100%(12/12)的鳞状细胞癌;93.2%(69/74)的鳞状上皮内高度病变,其中CIN3 96.8%(30/31),CIN2 90.7%(39/43);72.4%(92/127)的鳞状上皮内低度病变。常规脱落细胞学检出100%(12/12)的鳞状细胞癌;90.2%(66/74)的鳞状上皮内高度病变,其中CIN3 96.8%(30/31),CIN2 86.7%(36/43);71.1%(91/127)的鳞状上皮内低度病变。Thi-nprep液基细胞学对鳞状细胞癌和CIN3的分级准确率分别达100%和87.1%,常规脱落细胞学涂片对鳞状细胞癌和CIN3的分级准确率分别达100%和85.0%。结论:宫颈液基细胞学检测方法较比常规脱落细胞学检测敏感性高,尤其是对鳞状上皮内高度病变。
Objective: To evaluate the accuracy of Thinprep liquid-based cytology screening in cervical cancer. Methods: 1881 subjects underwent routine Pap smear Pap test, liquid-based specimen collection and colposcopy biopsy. The cytological diagnosis was based on the TBS grading system. The positive diagnosis included atypical squamous cell lesions of unknown significance. All Check both double-blind. Results: The squamous cell carcinoma with 100% (12/12) was detected by Thinprep liquid-based cytology and the high-grade squamous intraepithelial lesion was 93.2% (69/74) with CIN3 96.8% (30/31) and CIN2 90.7% (39/43), and 72.4% (92/127) of squamous intraepithelial lesion. The normal exfoliative cytology detected 100% (12/12) of squamous cell carcinoma; 90.2% (66/74) of squamous intraepithelial lesion, including CIN3 96.8% (30/31), CIN2 86.7% (36 / 43); 71.1% (91/127) of squamous intraepithelial lesion. Thi-nprep liquid-based cytology for squamous cell carcinoma and CIN3 grading accuracy rates were 100% and 87.1%, conventional cytology smears of squamous cell carcinoma and CIN3 grading accuracy were 100% and 85.0% . CONCLUSION: Cervical liquid-based cytology is more sensitive than conventional exfoliative cytology, especially to squamous intraepithelial lesion.