缺氧是肿瘤生长演进过程中的普遍现象,与肿瘤细胞的侵袭、转移、放、化疗的敏感性及预后密切相关。缺氧诱导因子-1(HIF-1)在人体恶性肿瘤中广泛存在,是缺氧条件下维持氧稳进的一种转录激活因子,能激活许多缺氧反应性表达的基因,对维持肿瘤细胞的能量代谢,新生血管生成,促进肿瘤 Hypoxia is a common phenomenon in the process of tumor growth and progression, which is closely related to the sensitivity and prognosis of tumor cells in invasion, metastasis, radiotherapy and chemotherapy. Hypoxia-inducible factor-1 (HIF-1) is widespread in human malignancies and is a transcriptional activator that maintains oxygen homeostasis under hypoxia and activates many hypoxia-responsive genes that contribute to the maintenance of tumor cells The energy metabolism, neovascularization, promote the tumor