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1引言抗感染药物一向是新药研发的重要领域。20世纪30年代Domagk发现百浪多息(prontosil)开创了现代意义的化学治疗领域。20世纪40年代Fleming发现了青霉素,形成了抗生素的治疗和半合成抗生素类药物。20世纪80年代喹诺酮类药物的诞生,对不断出现的耐药菌的感染增添了新的治疗手段。但自此以后的20年人们期待着新型抗菌药物的出现,所以,当2000年以利奈唑胺为代表的噁唑烷酮药物的诞生,作为新的作用靶标和药物类型,增添了新的武器。
1 Introduction Anti-infectives have always been an important area of research and development for new drugs. Domagk in the 1930s found that prontosil pioneered the field of chemotherapy in the modern sense. Fleming discovered penicillin in the 1940s, forming antibiotic-treated and semi-synthetic antibiotics. The birth of quinolones in the 1980s adds new therapeutic options to the emerging infections with resistant bacteria. However, since the advent of new antibiotics in 20 years from now, new oxazolidinone drugs, such as linezolid, represented by the year 2000, have been added as new targets and types of drugs .