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目的研究老年T2DM合并非酒精性脂肪性肝病(NAFLD)患者血清Vaspin水平的变化及其临床意义。方法测定老年T2DM合并NAFLD患者44例(T2DM+NAFLD组),老年T2DM不合并NAFLD患者40例(T2DM组),老年糖耐量正常的NAFLD患者40例(NAFLD组)与老年正常对照41名(NC组)的Vaspin水平。结果 T2DM+NAFLD组、T2DM组、NAFLD组血清Vaspin水平均明显高于NC组(1.46±0.43、1.03±0.27、0.76±0.28 vs 0.36±0.13)ng/ml,差异有统计学意义(P<0.01或P<0.05)。多元逐步回归分析显示FIns、内脏脂肪厚度(VFT)、HbA_1c是Vaspin水平的独立影响因素,Vaspin、VFT和TG是老年T2DM合并NAFLD的危险因素。结论血清Vaspin水平的变化可能在老年T2DM合并NAFLD的发生发展中起一定作用。
Objective To investigate the changes of serum Vaspin levels in elderly T2DM patients with non-alcoholic fatty liver disease (NAFLD) and its clinical significance. Methods Forty-four elderly patients with T2DM and NAFLD (T2DM + NAFLD group), 40 elderly patients with T2DM without NAFLD (T2DM group), 40 elderly NAFLD patients with NAFLD (NAFLD group) and 41 elderly controls Group) of Vaspin levels. Results The serum Vaspin levels in T2DM + NAFLD, T2DM and NAFLD groups were significantly higher than those in NC group (1.46 ± 0.43, 1.03 ± 0.27, 0.76 ± 0.28 vs 0.36 ± 0.13) ng / ml, with statistical significance (P <0.01 Or P <0.05). Multivariate stepwise regression analysis showed that FIns, visceral fat thickness (VFT) and HbA_1c were independent risk factors for Vaspin level. Vaspin, VFT and TG were risk factors for elderly T2DM with NAFLD. Conclusion The change of serum Vaspin may play a role in the occurrence and development of T2DM with NAFLD.