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利用电镜观察人胎盘绒毛的合胞体时,发现妊娠早期已有代表退化现象的合胞体结形成,此时合胞体结的核染色质分布均匀,近核区的粗面内质网渠扩大。从妊娠中期开始合胞体结的核染色质出现凝缩及边集,近核区粗面内质网渠扩大明显,并可见合胞体结游离面断裂及绒毛间隙有浓缩细胞核和部分胞质。发现提示合胞体细胞的凋亡是从形成合胞体结开始,再经过核染色质凝缩与边集及近核区粗面内质网渠的扩张,最后造成合胞体结游离面断裂及浓缩的核与部分胞质脱离合胞体
Observation of human placental syncytial cells by electron microscopy showed that syncytia formed during early gestation, representing degeneration, were formed. At this time, the distribution of nuclear chromatin in the syncytium junction was uniform and the enlargement of the rough endoplasmic reticulum in the proximal nuclear zone was observed. From the second trimester of pregnancy, the chromatin of syncytium in the syncytium showed condensed and marginal set, and the rough endoplasmic reticulum canal in the proximal nuclear zone expanded obviously. And the synaptic knot free surface rupture and villus interstitial nucleus and some cytoplasm were concentrated. It was found that the apoptosis of syncytial cells is from the formation of syncytium junction, and then through the nuclear chromatin condensation and marginal set and the proximal nuclear rough surface endoplasmic reticulum canal dilatation, resulting in syncytium knot free surface fracture and condensation Nuclear and part of cytoplasm from syncytia