放射-基因治疗是将放射敏感性调控序列与治疗基因相耦联,在肿瘤受照射时诱导治疗基因仅在肿瘤内表达,以提高治疗效率,是肿瘤治疗的一种新策略。Egr-1属即刻早期应答基因家族成员之一,是编码533个氨基酸的核酸蛋白转录因子,含6个高度保守的CC(A/T)_6GG结构域,又称为CArG元件。据报道CArG元件比天然的Egr-1基因射线应答性更强。本研究为了构建包含CArG元件 Radiation-gene therapy is the radiation-sensitive regulatory sequence coupled with the therapeutic gene, when the tumor is irradiated induced gene expression in the tumor only to improve the efficiency of treatment is a new strategy for cancer treatment. Egr-1, a member of the immediate early response gene family, is a 533-amino acid nucleic acid protein transcription factor with 6 highly conserved CC (A / T) 6GG domains, also known as CArG elements. The CArG element is reported to be more responsive than the native Egr-1 gene. This study was designed to construct a kit containing CArG elements