论文部分内容阅读
由聚甲基丙烯酸(PMAA)大分子单体参与的分散共聚反应,制得PMAA接枝聚苯乙烯(PSt-g-PMAA)共聚微球。通过扫描电子显微镜、Zeta电位及粒径分析仪对微球粒径与形态进行了表征;同时探讨了多种聚合反应条件(介质的极性、PMAA大分子单体的浓度和反应温度)对共聚微球粒径的影响,发现通过改变反应条件可有效地将微球的直径控制在340~1200nm的范围内;并发现微球在分散状态下对pH的变化有明显的响应性,该类共聚微球可望在药物负载和蛋白质吸附分离等方面得到应用。
PMAA grafted polystyrene (PSt-g-PMAA) copolymer microspheres were prepared by the dispersion copolymerization of poly (methacrylic acid) (PMAA) macromonomer. The particle size and morphology of the microspheres were characterized by scanning electron microscopy, Zeta potential and particle size analyzer. The effects of various polymerization conditions (the polarity of the medium, the concentration of PMAA macromer and the reaction temperature) It is found that the diameter of the microspheres can be effectively controlled within the range of 340-1200 nm by changing the reaction conditions. It is also found that the microspheres have obvious response to the change of pH in the dispersed state. Microspheres are expected to find applications in drug loading and protein adsorption and separation.