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采用饮水加氟、加硒的方法 ,用电镜和计算机图像分析仪分析研究了小鼠学习记忆相关脑区———海马CA3 区GrayI型突触后致密物质 (PSD)厚度的变化 ,并用生化方法测定了其脑内SOD活性的变化 .结果表明 :高氟能引起小鼠脑内海马CA3 区突触后致密物质厚度极显著变小 (P <0 .0 1或P <0 .0 0 1 )的病理性变化 ,并能降低其脑内SOD活性 ;适当量的硒可拮抗氟的这种作用 ,但硒量过高或过低则与氟产生协同毒性作用 .提示一定量的硒对氟致小鼠脑内突触结构损伤有改善作用 ,并且这种改善作用可能和硒提高其脑内SOD活性有关 .
The changes of gray matter-type synaptic density (PSD) in hippocampal CA3 region of mouse brain related to learning and memory were analyzed by electron microscopy and computer image analyzer. The biochemical methods The changes of SOD activity in brain were measured.The results showed that the high concentration of fluorine could significantly reduce the post-synaptic density of hippocampal CA3 area in hippocampus (P <0.01 or P <0.01) Of the pathological changes, and can reduce the SOD activity in the brain; the appropriate amount of selenium can antagonize this effect of fluorine, but excessive or too low selenium and produce synergistic toxic effects of fluorine. Prompted a certain amount of selenium to fluoride Synaptic structural damage in the brain of mice improved, and this improvement may be related to selenium increased SOD activity in the brain.