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目的 研究大剂量化疗结合自体干细胞移植提高化疗的效果。方法 1 9例淋巴瘤、乳腺癌、卵巢癌、多发性骨髓瘤和小细胞肺癌患者 ,有 1 7例接受骨髓干细胞移植 ,2例接受外周血干细胞移植。将干细胞 4℃保存 60～ 72h回输 ,期间给患者进行卡铂 +VP - 1 6+环磷酰胺方案或马法兰 +VP - 1 6 +环磷酰胺方案大剂量化疗。结果 所有病例的骨髓均被摧毁 ,移植后 1 8～ 44h骨髓完全恢复 ,治疗相关病死率为 0。 1 2例移植前为缓解的患者 ,1 1例仍然无病生存 ;7例移植前为复发者 ,均再缓解 ,但再复发 ,生存 1 0～ 2 8个月 ,总生存率 57.89%。结论 大剂量化疗联合自体造血干细胞移植支持治疗可明显提高完全缓解肿瘤患者的治愈率 ;对于复发或难治者 ,可以提高完全缓解率 ,延长生存期 ,提高生活质量
Objective To study the effect of high-dose chemotherapy combined with autologous stem cell transplantation to improve chemotherapy. Methods Twenty-nine patients with lymphoma, breast cancer, ovarian cancer, multiple myeloma and small cell lung cancer received bone marrow stem cell transplantation and two received peripheral blood stem cell transplantation. The stem cells were stored at 4 ° C for 60-72h before transfusion. Patients were given high dose chemotherapy of carboplatin + VP - 1 6+ cyclophosphamide or melphalan + VP - 1 6 + cyclophosphamide. RESULTS: Bone marrow was destroyed in all cases. Bone marrow recovered completely between 18 and 44 hours after transplantation with a treatment-related mortality of 0%. Of the 12 patients who had been treated with mitigation, 11 remained disease-free and 7 had recurrence before transplantation. All patients were re-relapsed and survived 10 to 28 months with a total survival rate of 57.89%. Conclusion High-dose chemotherapy combined with autologous hematopoietic stem cell transplantation can significantly improve the cure rate of patients with complete remission; for patients with recurrent or refractory, complete remission rate, prolonged survival and quality of life can be improved