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目的观察低分子肝素钙(LMWH)联合丹参治疗早发型重度子痫前期的有效性及安全性。方法选取医院收治的早发型重度子痫前期患者160例为研究对象,随机分为2组,每组80例。在基础治疗的同时,对照组给予硫酸镁加盐酸拉贝洛尔治疗,观察组给予LMWH加丹参注射液治疗。动态观察2组治疗效果、母婴结局及并发症发生情况。结果观察组治疗效果优于对照组,新生儿重度窒息发生率低于对照组,新生儿出生时体重大于对照组,延长妊娠时间优于对照组,并发症发生率低于对照组,2组比较差异均有统计学意义(P<0.01或P<0.05)。结论对早发型重度子痫前期患者,在常规治疗的基础上应用LMWH联合丹参治疗效果较好,能有效降低孕产妇的血压,适当延长孕周,明显改善凝血功能及母婴结局,值得临床推广应用。
Objective To observe the efficacy and safety of low molecular weight heparin (LMWH) combined with Salvia miltiorrhiza in the treatment of early-onset severe preeclampsia. Methods A total of 160 early-onset severe preeclampsia patients admitted to hospital were selected as study subjects and randomly divided into two groups (n = 80 in each group). At the same time as the basic treatment, the control group was given magnesium sulfate plus labetalol, and the observation group was given LMWH plus salvia miltiorrhiza injection. Dynamic observation of two groups of treatment, maternal and child outcomes and complications. Results The observation group was better than the control group. The incidence of neonatal severe asphyxia was lower than that of the control group. The newborn’s birth weight was greater than that of the control group. The prolongation of gestation time was better than that of the control group. The incidence of complications was lower than that of the control group. The differences were statistically significant (P <0.01 or P <0.05). Conclusion Early treatment of patients with severe preeclampsia, LMWH combined with Salvia on the basis of conventional treatment is better, can effectively reduce the blood pressure of pregnant women, prolong gestational age, significantly improve the coagulation function and maternal and infant outcomes, is worthy of clinical promotion application.