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0引言与张力蛋白同源的10号染色体缺失的磷酸酶基因(phosphatase and tensin hemology deleted on chromosome ten gene,PTEN)是1997年发现的编码具有脂质磷酸酶和蛋白磷酸酶活性的抑癌基因,具有双重肿瘤抑制功能。此后研究发现在多种实体瘤中存在PTEN基因的突变、等位基因的缺失或低
0 Introduction Phosphatase and tensin hemogram deleted on chromosome ten genes (PTEN) homologous to tensin homology is a tumor suppressor gene encoding a phosphatase and protein phosphatase activity found in 1997, With dual tumor suppression. Subsequent studies have found mutations in the PTEN gene, deletions or low alleles in a variety of solid tumors