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Ｓｐｉｔｚ痣的组织结构模式和细胞学与黑素瘤(ＭＭ)的垂直生长期相似 ,有时在形态学上难以区别。细胞周期蛋白Ｄ1 是一种通过调节转录因子Ｅ2Ｆ 1的功能 ,促进细胞从Ｇ1 期进展到Ｓ期的调节蛋白。Ｉｎｏｈａｒａ曾报告细胞周期蛋白Ｄ1 在ＭＭ中过度表达 ,而获得性痣中少见。假
Spitz nevus histological patterns and cytology and melanoma (MM) of the vertical growth period is similar, sometimes difficult to distinguish morphologically. Cyclin D1 is a regulatory protein that promotes cell progression from the G1 phase to the S phase by regulating the function of the transcription factor E2F1. Inohara has reported that cyclin D1 is overexpressed in MM, but rare in acquired nevus. false