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采用原位灌注方法分离大鼠肝细胞和储脂细胞 (Ito细胞 ) ,观察微量元素硒 (Se)对CCl4 作用下大鼠肝细胞、Ito细胞细胞外基质 (ECM)产生的拮抗作用。实验结果表明 :Se主要通过提高CCl4 作用下肝细胞、Ito细胞谷胱甘肽过氧化物酶(GPx)活性 ,阻止脂质过氧化损伤 ,继而抑制两种细胞Ⅲ型前胶原 (PCⅢ )分泌以及Ito细胞EMG的分泌
In situ perfusion method was used to separate rat hepatocytes and lipofection cells (Ito cells), and the antagonism of trace element selenium (Se) to the extracellular matrix (ECM) of rat hepatocytes and Ito cells under CCl4 stimulation was observed. The experimental results show that Se enhances the activity of glutathione peroxidase (GPx) in hepatocytes and Ito cells by inhibiting the peroxidation of lipid peroxidation induced by CCl4, and then inhibits the secretion of type Ⅲ procollagen (PCⅢ) Ito cell EMG secretion