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作者应用单克隆抗肌动蛋白抗体(HUC(?)-1,1 A4)、抗角蛋白抗体(AE-1,34βE12)和抗波形蛋白抗体(V 9),通过免疫组化法检测了23例多形性肿瘤、22例囊腺癌和17例正常涎腺,以确定多形性腺瘤和囊腺癌二者是否来源于肌上皮细胞。作者认为有两种特异性抗肌动蛋白单克隆抗体(HUC 1-1和1 A4),它们不仅能辨认β-和α-细肌浆肌动蛋白,而且还能与肌肉肌动蛋白发生反应。因此,这两种抗体可特异性地检测涎腺肿瘤中的肌上皮成分。肌动蛋白是微丝中普遍存在的细胞骨架蛋白,它大量存在于肌肉中。细胞类型不同,所含有肌动蛋白的生物学性质不同。在正常涎腺
Authors with monoclonal anti-actin antibody (HUC(?)-1,1 A4), anti-keratin antibody (AE-1,34?E12) and anti-vimentin antibody (V 9), were examined by immunohistochemistry A pleomorphic tumor, 22 cystadenocarcinomas, and 17 normal parotid glands were used to determine whether pleomorphic adenoma and cystadenocarcinoma were derived from myoepithelial cells. The authors believe that there are two specific anti-actin monoclonal antibodies (HUC 1-1 and 1 A4) that not only recognize β- and α-skeletal plasma actin but also react with muscle actin . Therefore, these two antibodies can specifically detect the myoepithelial component in salivary gland tumors. Actin is a ubiquitous cytoskeletal protein in microfilaments that is abundant in muscle. Different cell types contain different biological properties of actin. In the normal parotid gland