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川芎为伞形科植物川芎的根茎,具有活血行气、祛风止痛的功效。川芎嗪是中药川芎的有效成分之一,具有扩张血管、抗血小板凝聚、抗血栓形成、减轻血管痉挛和改善微循环等作用,临床主要用于闭塞性脑血管疾病如脑供血不足、脑血栓形成、脑栓塞等。随着社会的老龄化和心脑血管疾病患者的增加,川芎嗪注射液的临床应用范围日益扩大。现将近10年来有关盐酸川芎嗪的临床应用和配伍禁忌及不良反应文献进行综述,指导临床合理用药。
Chuanxiong is the root of Umbelliferae Rhizoma, has the effect of promoting blood circulation, expelling wind and relieving pain. Ligustrazine is one of the active ingredients of Ligusticum chuanxiong. It has the functions of dilating blood vessels, anti-platelet aggregation, anti-thrombosis, reducing vasospasm and improving microcirculation. It is mainly used in occlusive cerebrovascular diseases such as cerebral insufficiency, cerebral thrombosis , Cerebral embolism and so on. With the aging of the society and the increase of patients with cardiovascular and cerebrovascular diseases, the clinical application range of ligustrazine injection is expanding day by day. Now nearly 10 years of tetramethylpyrazine hydrochloride clinical application and incompatibility and adverse drug reactions literature review to guide the rational use of clinical medicine.