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温胃舒冲剂是根据临床实践组成的中药复方制剂．为了探讨其作用机理．用小鼠造成３种模型：去氧胆酸钠（ＤＯＣＡ）造成慢性萎缩性胃炎（ＣＡＧ）模型；ＤＯＣＡ＋甲疏基咪唑造成 ＣＡＧ－阳虚模型，ＤＯＣＡ＋甲状腺＋利血平造成 ＣＡＧ－阴虚模型。以血浆中环磷酸腺苷（ｃＡＭＰ ）、环磷酸鸟苷（ｃＧＭＰ）观察其治疗作用。结果表明，温胃舒能降低ＣＡＧ模型小鼠的ｃＡＭＰ、ｃＧＭＰ．也能降低ＣＡＧ－阳虚模型小鼠的ｃＧＭＰ，与模型对照组比较均Ｐ＜０．０５～０．０１。此外．结果还表明温胃舒冲剂有镇痛、抗炎和抑制胃肠推进运动、并能提高大鼠淋巴细胞转化率、血清ＩｇＧ水平。
Wenweishu granules are traditional Chinese medicine compound preparations based on clinical practice. In order to explore its mechanism of action. Three models were created in mice: a chronic atrophic gastritis (CAG) model caused by sodium deoxycholate (DOCA); a CAG-yang deficiency model caused by DOCA + methyi imidazole; a CAG-hypoxemia model caused by DOCA + thyroid + reserpine . The therapeutic effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) was observed in plasma. The results showed that Wenweishu can reduce the cAMP and cGMP in CAG mice. It can also reduce the cGMP in mice with CAG-yang deficiency model, and P<0.05-0.01 compared with the model control group. In addition. The results also showed that Wenweishu Granules have analgesic, anti-inflammatory and gastrointestinal propulsion activities, and can increase lymphocyte transformation rate and serum IgG levels in rats.