应用单克隆抗体和ABC免疫酶标方法对30例慢性活动性乙型肝炎患者外周血及部分患者肝活检组织中T细胞亚群的分布和变化与健康对照外周血T细胞亚群比较进行了观察。结果表明:T_1阳性细胞比例无显著差异。T_4阳性细胞比例明显减少,T_8阳性细胞比例明显增加,T_4/T_8比值明显降低。P值均小于0.01。CAH-B患者肝活检组织中,肝细胞点、片状坏死区周围浸润的细胞为T_8阳性的淋巴T细胞。 The distribution and changes of T lymphocyte subsets in peripheral blood of patients with chronic active hepatitis B and in some patients’ liver biopsies were observed by monoclonal antibody and ABC immunoenzyme labeling method compared with that of healthy controls . The results showed that there was no significant difference in the proportion of T 1 positive cells. The proportion of T 4 positive cells was significantly decreased, the proportion of T 8 positive cells was significantly increased, and the ratio of T 4 / T 8 was significantly decreased. P values ​​are less than 0.01. In the liver biopsy of CAH-B patients, the infiltrating cells around the hepatocytes and the platelet necrosis area were T8-positive lymphoid T cells.