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目的 :为研究食管癌病人癌组织中 myc基因的扩增情况 ,探讨 myc基因与食管癌浸润和转移的关系。方法 :采用聚合酶链反应 (PCR)进行测定。结果 :淋巴结转移阳性组的 myc基因扩增率 (71.4% )明显高于淋巴结转移阴性组 (16 .7% ) ,且myc族癌基因的扩增率随癌浸润程度的加重而增高 ,具有明显相关性 (P<0 .0 5 )。结论 :myc族癌基因的过表达与食管癌的浸润和转移关系密切 ,m yc基因的表达情况可作为评价食管癌预后新的指标。
Objective: To study the amplification of myc gene in esophageal cancer and explore the relationship between myc gene and esophageal cancer invasion and metastasis. Methods: Polymerase chain reaction (PCR) was used for the determination. Results: The rate of myc gene amplification (71.4%) in lymph node positive group was significantly higher than that in negative lymph node metastasis group (16.7%), and the amplification rate of myc family oncogene was increased with the degree of cancer infiltration, with obvious Correlation (P <0.05). Conclusion: The overexpression of myc family of oncogenes is closely related to the invasion and metastasis of esophageal cancer. The expression of m yc gene may be a new index to evaluate the prognosis of esophageal cancer.