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目的研究重组人促红细胞生成素(r-HuEPO)对慢性肾功能衰竭(CRF)患者营养状态及凝血功能的影响。方法随机抽取CRF患者20名(对照组)及规律使用r-HuEPO CRF患者25名(观察组),测定其血中血红蛋白(Hb)、肌酐(CRE)、视黄醇结合蛋白(RBP)、前白蛋白(PA)、转铁蛋白(TRF)和纤维蛋白原/纤维蛋白降解产物(FDP)浓度,并与对照组比较。结果对照组的Hb、PA、RBP和TRF浓度明显低于观察组,FDP浓度明显高于观察组;两组CRE浓度差异无显著意义;Hb与PA、TRF与RBP浓度呈正相关,与FDP浓度呈负相关;CRE与PA、TRF、RBP和FDP浓度无相关性。结论使用r-HuEPO在纠正CRF患者贫血后,可以改善其营养状态,降低其体内的高凝因素。
Objective To investigate the effect of recombinant human erythropoietin (r-HuEPO) on the nutritional status and coagulation function in patients with chronic renal failure (CRF). Methods Twenty patients with CRF (control group) and 25 patients with regular r-HuEPO CRF (observation group) were randomly selected. The levels of hemoglobin (Hb), creatinine (CRE), retinol binding protein (RBP) Albumin (PA), transferrin (TRF) and fibrinogen / fibrin degradation product (FDP) were measured and compared with the control group. Results The concentrations of Hb, PA, RBP and TRF in the control group were significantly lower than those in the observation group, and the concentrations of FDP in the control group were significantly higher than those in the observation group. There was no significant difference in CRE concentration between the two groups. Negative correlation; CRE and PA, TRF, RBP and FDP concentration was not related. Conclusion The use of r-HuEPO in the correction of anemia in patients with CRF can improve their nutritional status, reducing the body’s hypercoagulability factors.