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目的制备连萸总碱胃内释药片,评价其体外释药性能。方法以羟丙基甲基纤维素为亲水性凝胶骨架,碳酸氢钠为起泡剂制备漂浮型胃内释药片,以释放度、漂浮性能以及外观作为考察指标,用正交设计法优化制剂配方。结果胃内释药片能在人工胃液中立即起漂,体外漂浮时间达12h以上,1～12h的体外释放符合Peppas方程。结论优化处方的连萸总碱胃内释药片漂浮性能好、缓释效果明显。
OBJECTIVE To prepare the intragastric release tablets of Lincomycin alkaloids and evaluate its in vitro drug release properties. Methods Floating intragastric release tablets were prepared with hydroxypropyl methylcellulose as hydrophilic gel matrix and sodium bicarbonate as foaming agent. The release degree, floating performance and appearance were taken as the indexes of study. The orthogonal design method was used to optimize Formulation formulation. Results The intragastric release tablets could immediately float in the artificial gastric juice, the floating time in vitro was above 12h, and the in vitro release in 1-12h was in accordance with the Peppas equation. Conclusion Optimized prescription linalool alkaloids release tablets stomach floating good performance, sustained-release effect is obvious.