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目的:研究诺和锐30联合拜唐苹治疗初诊T2DM的疗效及对胰岛β细胞功能的恢复情况。方法:160例初诊T2DM住院患者予诺和锐30联合拜唐苹治疗,并根据血糖水平调整胰岛素剂量,控制FPG<7.0 mmol/L、2 h PG<10 mmol/L;患者出院后继续上述治疗,并每2周到门诊复诊1次,以调整胰岛素用量;达标3个月后停用诺和锐30及拜唐苹。结果:治疗后患者的FPG、2 h PG和HbA1c均明显降低,而血清胰岛素、C肽变化均显著升高,与治疗前比较差异有统计学意义(P<0.01);结论:早期T2DM患者采用诺和锐30联合拜唐苹短期强化治疗效果较好,可以很好地控制患者的血糖、改善胰岛β细胞功能、减轻胰岛素抵抗,其对于延缓糖尿病病程进展具有深远意义。
OBJECTIVE: To study the curative effect of Novo-Rui-30 combined with Baitipan on newly diagnosed T2DM and the recovery of pancreatic β-cell function. Methods: 160 patients with newly diagnosed T2DM were treated with Novo-Rui-Rui 30 and metopride, and the insulin dosage was adjusted according to blood glucose level to control FPG <7.0 mmol / L and PGI <10 mmol / L for 2 h. , And every 2 weeks to the outpatient referral 1 times, to adjust the amount of insulin; 3 months after the standard out of Novo Rui 30 and thanks to Tang Ping. Results: The levels of FPG, 2 h PG and HbA1c in patients after treatment were significantly decreased, while the levels of serum insulin and C peptide were significantly increased (P <0.01). Conclusion: The early T2DM patients Nuo-Rui-Rui-30 combination of peritonidine short-term intensive treatment is better, can control the patient’s blood sugar, improve pancreatic β-cell function, reduce insulin resistance, which is of far-reaching significance to delay the progression of diabetes.