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目的探讨伊曲康唑注射液在重症监护病房(ICU)侵袭性真菌感染患者治疗中的应用。方法选取2014年1月至2015年12月于营口市中心医院治疗的ICU侵袭性真菌感染患者86例为研究对象,按随机数字表法分为观察组与对照组,每组43例。观察组患者给予伊曲康唑注射液治疗,对照组患者给予氟康唑治疗,比较两组患者的治疗效果及不良反应发生情况。结果观察组患者的总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组患者真菌清除率明显高于对照组,差异有统计学意义(P<0.05);观察组患者不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论伊曲康唑注射液治疗ICU侵袭性真菌感染患者能有效清除真菌,治疗效果显著,安全性高。
Objective To investigate the application of itraconazole injection in the treatment of patients with invasive fungal infection in intensive care unit (ICU). Methods Totally 86 patients with ICU invasive fungal infection who were treated in Yingkou Central Hospital from January 2014 to December 2015 were selected and divided into observation group and control group according to random number table method, with 43 cases in each group. Patients in the observation group were treated with itraconazole injection, while patients in the control group were treated with fluconazole. The treatment effect and adverse reactions in both groups were compared. Results The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). The fungal clearance rate in the observation group was significantly higher than that in the control group (P <0.05) The incidence of adverse reactions in patients was significantly lower than that in the control group, with statistical significance (P <0.05). Conclusion Itraconazole injection in patients with ICU invasive fungal infection can effectively remove fungi, the treatment effect is significant and safe.