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目的 :研究舒痛安胶囊 (STAC)的益气、补血、止痛、镇静和催眠作用。方法 :采用限食性气虚、急性出血性血虚小鼠模型 ,热板法、扭体法、自主活动和戊巴比妥钠睡眠时间试验方法。结果 :STAC有显著对抗气虚小鼠的体重、血红蛋白(Hb)含量和T淋巴细胞ANAE阳性率的下降 ,显著抑制限食所致的胸腺萎缩 ,显著提高急性失血性“血虚”小鼠的Hb含量 ,减少醋酸性扭体反应次数和延长热刺激致痛的潜伏期 ,减少小鼠自主活动时间和抬前脚次数 ,协同戊巴比妥钠促进小鼠睡眠。结论 :实验结果提示其具有益气、补血、止痛、镇静催眠作用。
Objective: To study the effects of qi, blood, analgesia, sedation and hypnosis in STAC. METHODS: The experimental models of mice with food-deficit qi deficiency, acute hemorrhagic blood deficiency, hot plate method, writhing method, autonomic activity and pentobarbital sodium sleep time were used. RESULTS: STAC significantly decreased body weight, hemoglobin (Hb) content, and ANAE positive rate of T lymphocyte in mice with qi deficiency, significantly inhibited thymus atrophy due to food restriction, and significantly improved the Hb of acute hemorrhagic blood deficiency mice. Content, reduce the number of acetic acid writhing reaction and prolong the incubation period of thermal stimulation, reduce the time of the mice’s spontaneous activity and raise the number of forefoot, and cooperate with sodium pentobarbital to promote sleep in mice. Conclusion : The experimental results suggest that it has the effects of supplementing Qi, blood, analgesia, and sedative and hypnotic effects.