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Up to now,there are more than15thousands of mi RNAs cloned from142different species(Sep.2010,mi RBase16.0),among which1048are fromhuman being.Computational predictions basing on ge-nome sequencesindicate that there are1000to10,000human mi RNAgenes.There should be more humanmi RNAs waiting to be discovered.[1,2]However,the identification of human novel mi RNA becomes moreand more difficult withroutine methods.In2009,no more than30human mi RNAs have beenfound(Sep.2008,mi RBase Release12.0,Jan.2010,mi RBase Release14.0).Although advancedtechnologies such asmicroarray,dee
Up to now, there are more than 15thousands of miRNAs cloned from 1422 different species (Sep.2010, mi RBase16.0), among which 1048are fromhuman being. Computational predictions basing on ge-nome sequencesindicate that there are1000to10,000human mi RNAgenes. There should be more [1,2] However, the identification of human novel mi RNA becomes more and more difficult withroutine methods. 2009, no more than 30 human miRNAs have been found (Sep. 2008, mi RBase Release 12.0, Jan., 2010, mi RBase Release 14.0) .Although advanced technologies such as microarray, dee