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布加综合征与门静脉血栓是2种罕见的肝脏血管病,可伴发肝功能衰竭及门静脉高压症等严重并发症。研究证据表明因子V Leiden(FVL)突变是西方布加综合征与门静脉血栓患者的重要危险因素,但在中国布加综合征患者中比较罕见。着重回顾FVL突变在布加综合征与门静脉血栓形成中的意义,提出尚须前瞻性研究进一步评估FVL突变在中国门静脉血栓患者中的患病率,以判断FVL突变筛查的必要性。
Budd-Chiari syndrome and portal vein thrombosis are two rare forms of hepatic vascular disease that can be associated with serious complications such as liver failure and portal hypertension. Evidence shows that factor V Leiden (FVL) mutation is an important risk factor in patients with Budd-Chiari syndrome and portal vein thrombosis in the West, but rare in patients with Budd-Chiari syndrome in China. Emphasizing the significance of FVL mutation in Budd-Chiari syndrome and portal vein thrombosis, we proposed the need of prospective study to further evaluate the prevalence of FVL mutation in Chinese patients with portal vein thrombosis in order to determine the screening of FVL mutations.