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目的评价左奥硝唑氯化钠注射液治疗口腔厌氧菌感染的临床疗效与安全性。方法采用随机、双盲、平行对照研究。入组60例口腔厌氧菌感染患者均分为两组,分别静脉滴注左奥硝唑-氯化钠注射液(试验组)或奥硝唑-氯化钠注射液(对照组),剂量均为0.5 g,每日2次,3~5 d为1个疗程。评价药物疗效及安全性。结果试验组患者用药后痊愈率96.67%,对照组为90.00%(P>0.05)。试验组细菌清除率为100.00%,对照组为83.33%(P>0.05)。试验组不良反应发生率为0,明显低于对照组的23.33%(P<0.01)。结论左奥硝唑治疗口腔厌氧菌感染安全有效。
Objective To evaluate the clinical efficacy and safety of left ornidazole and sodium chloride injection in the treatment of oral anaerobic infections. Methods Randomized, double-blind, parallel-controlled study. Sixty patients with oral anaerobic infections were divided into two groups. The patients were treated with either left ornidazole-sodium chloride injection (experimental group) or ornidazole and sodium chloride injection (control group) Both 0.5 g, 2 times a day, 3 ~ 5 d for a course of treatment. Evaluation of drug efficacy and safety. Results The cure rate of the test group was 96.67% after treatment and 90.00% in the control group (P> 0.05). The bacterial clearance rate was 100.00% in the test group and 83.33% in the control group (P> 0.05). The incidence of adverse reactions in the experimental group was 0, which was significantly lower than that in the control group (23.33%, P <0.01). Conclusion Left ornidazole treatment of oral anaerobic infections safe and effective.