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以恩诺沙星为模板分子,甲基丙烯酸为功能单体,三羟甲基丙烷三甲基丙烯酸酯为交联剂制备恩诺沙星印迹聚合物,并通过吸附试验优化其合成条件。通过扫描电镜、红外光谱分析和吸附试验表征印迹聚合物的性质,并测定了各印迹聚合物在4种不同pH值介质中的药物释放性能。当模板分子∶功能单体∶交联剂的比例为1∶8∶6时合成的印迹聚合物的吸附性能最佳。Scatchard模型分析显示,最佳条件下制备的印迹聚合物的最大表观结合量为66.8 mg/g。该印迹聚合物重新载药后的体外释放行为呈pH依赖性,但突释现象较严重。
The enrofloxacin imprinted polymer was prepared using enrofloxacin as a template molecule, methacrylic acid as a functional monomer and trimethylolpropane trimethacrylate as a crosslinking agent, and its synthesis conditions were optimized by adsorption experiments. The properties of the imprinted polymers were characterized by scanning electron microscopy, infrared spectroscopy and adsorption experiments. The drug release properties of each imprinted polymer in four different pH media were also determined. When the ratio of template molecule: functional monomer: crosslinking agent is 1: 8: 6, the synthesized imprinted polymer has the best adsorption property. Scatchard model analysis showed that the maximum apparent binding capacity of imprinted polymer prepared under the optimal conditions was 66.8 mg / g. The in vitro release behavior of the imprinted polymer after reloading was pH-dependent, but the phenomenon of burst release was more serious.