细胞凋亡与增殖的动态平衡是维系生长发育、内环境稳定和免疫调节所必需的基本过程,此平衡破坏所导致的细胞凋亡抵抗是肿瘤发生发展的重要原因之一。细胞凋亡是一个复杂的细胞程序性死亡的过程,该过程涉及一系列复杂的生化反应,受多种分子的调节,其关键分子的表达异常和功能 The dynamic balance between apoptosis and proliferation is the basic process necessary to maintain the growth and development, the stability of the internal environment and the immune regulation. The apoptosis resistance caused by the balance destruction is one of the important reasons for tumor development. Apoptosis is a complex process of programmed cell death that involves a complex series of biochemical reactions that are regulated by a variety of molecules and whose aberrant expression and function of key molecules