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目的:了解广东省沙门菌等几种重要食源性致病的耐药状况及耐药谱。方法:参照CLSI推荐的琼脂扩散法。结果:受试的72株沙门菌和6株O157:H7大肠杆菌中,分别只有1株对14种抗生素全部敏感。132株副溶血性弧菌中没有对这14种抗生素全部敏感的菌株。32株单核细胞增生李斯特氏菌对14种抗生素的敏感度较高,但25.0%的菌株同时对磺胺类和头孢曲松耐药。同时对5种以上抗生素耐药的菌株构成比:沙门菌为25.0%,有13种耐药谱;副溶血性弧菌为45.5%,有21种耐药谱;O157:H7大肠杆菌为83.3%,有4种耐药谱。结论:广东省4种食源性致病菌的耐药状况十分普遍。食物中毒分离株中产生多重耐药的比例较高。多重耐药株呈逐年上升的趋势。必须高度重视食源性致病菌的耐药性对食品安全及人类健康的影响。
Objective: To understand the drug resistance and drug resistance of several important food-borne pathogens in Guangdong Province. Methods: Refer to CLSI recommended agar diffusion method. Results: Of the 72 Salmonella strains and 6 O157: H7 Escherichia coli strains tested, only 1 strain was sensitive to 14 antibiotics. 132 strains of Vibrio parahaemolyticus are not all of the 14 kinds of antibiotics susceptible strains. 32 strains of Listeria monocytogenes were highly susceptible to 14 antibiotics, but 25.0% strains were resistant to both sulfonamides and ceftriaxone. At the same time, the composition ratio of the strains resistant to more than five kinds of antibiotics was: Salmonella was 25.0%, there were 13 kinds of resistance spectrum; Vibrio parahaemolyticus was 45.5%, there were 21 kinds of drug resistance spectrum; O157: H7 Escherichia coli was 83.3% , There are four kinds of resistance spectrum. Conclusion: The prevalence of four food-borne pathogens in Guangdong Province is very common. Food poisoning isolates produce a higher proportion of multi-drug resistance. Multi-drug resistant strains showed an upward trend year by year. The importance of foodborne pathogenic resistance to food safety and human health must be given high priority.