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目的观察硝苯地平联合硫酸镁治疗重度妊娠高血压疾病对患者血流动力学与肾功能的影响。方法将重度妊娠高血压疾病患者220例随机分为观察组和对照组各110例。对照组给予硫酸镁等常规治疗,观察组在对照组基础上给予硝苯地平治疗。对比观察2组患者治疗前后血流动力学与肾功能各项指标的变化情况。结果治疗前2组患者红细胞压积、血黏度、阻力指数(RI)、脐动脉舒张压血流峰速比值(S/D)、24h尿蛋白量、24h尿肌酐量比较差异均无统计学意义(P>0.05),治疗后上述指标均显著改善,且观察组改善情况均明显优于对照组(P<0.05)。结论硝苯地平联合硫酸镁治疗重度妊娠高血压疾病的临床效果显著,能有效地改善患者血流动力学与肾功能,可有效改善患者的临床症状与体征,降低血压、控制水肿、保护肾脏、控制蛋白尿值得临床推广应用。
Objective To observe the effects of nifedipine and magnesium sulfate on hemodynamics and renal function in patients with severe pregnancy-induced hypertension. Methods 220 patients with severe pregnancy-induced hypertension were randomly divided into observation group and control group of 110 cases. The control group was given conventional therapy such as magnesium sulfate. The observation group was given nifedipine on the basis of the control group. The changes of hemodynamics and renal function before and after treatment in two groups were observed. Results There was no significant difference in hematocrit, blood viscosity, resistance index (RI), peak / diastolic blood flow velocity ratio (S / D), 24h urinary protein and 24h urinary creatinine between the two groups before treatment (P> 0.05). After treatment, the above indexes were significantly improved, and the improvement in the observation group were significantly better than the control group (P <0.05). Conclusion Nifedipine combined with magnesium sulfate in the treatment of severe pregnancy-induced hypertension has significant clinical effect, which can effectively improve the patient’s hemodynamics and renal function, which can effectively improve the clinical symptoms and signs, reduce blood pressure, control edema, protect the kidneys, Controlled proteinuria worthy of clinical application.