论文部分内容阅读
目的观察三维适形放疗(3 dCRT)食管癌术后纵膈淋巴结转移的疗效及毒副反应。方法对安阳市肿瘤医院收治的48例胸中段食管癌术后纵隔淋巴结复发患者采用3 dCRT,常规分割,放疗剂量2Gy/次,5次/周,总剂量50～60Gy/25～30次,5～6周。结果 48例食管癌术后纵隔淋巴结复发患者全部于治疗后1个月行胸部CT或颈部彩超检查,完全缓解(CR)27例,部分缓解(PR)9例,稳定(SD)7例,进展(PD)5例。总有效率(CR+PR)75.0%。所有患者均得到回访,1、2、3年生存率分布为91.7%、63.2%、45.8%。毒副反应主要为急性放射性食管炎、放射性气管炎,全组未出现放射性皮炎,恶心、呕吐和骨髓抑制等。结论 3 d-CRT治疗食管癌术后纵膈淋巴结转移安全有效。
Objective To observe the curative effect and toxicity of postoperative mediastinal lymph node metastasis of three-dimensional conformal radiation therapy (3 dCRT) esophageal cancer. Methods 48 cases of esophageal carcinoma of the thoracic esophagus were treated by 3 dCRT in patients with recurrent esophageal cancer after operation. The patients were divided into two groups according to the dose of 2Gy / time, 5 times / week and the total dose of 50-60Gy / 25-30 ~ 6 weeks. Results All 48 cases of esophageal cancer patients with mediastinal lymph node recurrence were examined by chest CT or cervical ultrasonography one month after treatment. There were 27 cases of complete remission (CR), 9 cases of partial remission (PR), 7 cases of stable (SD) Progress (PD) in 5 cases. Total effective rate (CR + PR) 75.0%. All patients were followed up. The 1, 2, 3 year survival rates were 91.7%, 63.2% and 45.8% respectively. Toxic side effects mainly acute esophagitis, radiation bronchitis, the whole group did not appear radiation dermatitis, nausea, vomiting and bone marrow suppression. Conclusion 3 d-CRT treatment of esophageal cancer after mediastinal lymph node metastasis is safe and effective.