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目的了解云南省不同地区傣族儿童G6PD缺乏症的流行病学现状。方法对云南省3个不同地区3 075名傣族儿童采用荧光斑点试验和G6PD/6PGD定量比值法检测进行G6PD缺乏症筛查,并进行统计学分析。结果G6PD缺乏症检出率为4.8%,男童为6.8%,女童为2.8%,不同年龄G6PD缺乏率男女童有明显差异,男童明显高于女童;G6PD缺乏率以傣族(新平县)9.7%居首,各地区之间差异有统计学意义。结论G6PD缺乏率男童高于女童,符合X伴性遗传方式;G6PD缺乏症的分布与地域有关,开展遗传咨询及进行G6PD检测为G6PD缺乏症的预防提供了有价值的基础资料。
Objective To understand the epidemiological status of G6PD deficiency among Dai children in different areas of Yunnan Province. Methods A total of 3 075 Dai children from 3 different areas in Yunnan Province were tested for G6PD deficiency by fluorescent speckle test and G6PD / 6PGD quantitative ratio method, and statistical analysis was made. Results The prevalence of G6PD deficiency was 4.8% in boys and 6.8% in boys and 2.8% in girls. There was a significant difference between boys and girls in G6PD prevalence at different ages. The prevalence of G6PD in girls was significantly lower in Dai (Xinping) 9.7 % Top, the differences between various regions have statistical significance. Conclusions The prevalence of G6PD deficiency in boys is higher than that in girls, and the distribution of G6PD deficiency is related to geographical areas. Genetic counseling and G6PD testing provide valuable information for the prevention of G6PD deficiency.