临床使用的药物中,有很多能直接或间接地使血清钾升高而导致高血钾。本文从药物的副反应角度,对引起血清钾升高的药物作一综述,供临床参考。 一、保钾利尿剂:这类药物能阻止肾远曲小管和集合管泌钾,而远曲小管和集合管分泌的钾约占肾脏泌钾的90％,使用不当可导致高血钾。其作用机理分为:(一)直接拮抗盐皮质激素,如安体舒通, Many of the drugs used clinically can raise serum potassium, either directly or indirectly, leading to hyperkalemia. This article from the perspective of side effects of drugs on the rise of serum potassium drugs made a review for clinical reference. First, potassium-sparing diuretics: these drugs can prevent renal distal convoluted tubules and collection of potassium, and far convoluted tubules and collecting tube secretion of potassium accounts for about 90% of kidney potassium, improper use can lead to hyperkalemia. Its mechanism of action is divided into: (a) direct antagonism of mineralocorticoid, such as spironolactone,