论文部分内容阅读
目的考察依达拉奉凝胶体外经皮渗透性,筛选凝胶剂最佳处方。方法采用Valin-Chien双室渗透扩散池,以大鼠离体皮肤为渗透屏障,以HPLC测定依达拉奉的浓度,考察含药量、月桂氮?酮用量、环糊精的型号和含量对依达拉奉凝胶剂经皮渗透性的影响。结果凝胶剂最佳处方为6%依达拉奉、10%月桂氮?酮、10%β-环糊精、2%羧甲基纤维素钠,依达拉奉12 h累积渗透量平均值为(501.95±27.59)μg·cm?2,渗透速率平均值为(42.25±7.39)μg·cm?2·h?1。结论依达拉奉凝胶剂具有较好的经皮渗透特性,有望成为新的给药制剂。
Objective To investigate the transdermal permeability of edaravone gel in vitro and to screen the best prescription of gel. Methods Valin-Chien dual-chamber osmotic diffusion cells were used in vitro. The skin of rats was used as the permeation barrier. The concentration of edaravone was determined by HPLC. The drug content, the dosage of laurocapram, the type and content of cyclodextrin Effect of edaravone gel on percutaneous permeability. Results The best prescription of gel was 6% edaravone, 10% laurocapram, 10% β-cyclodextrin, 2% sodium carboxymethylcellulose and edaravone, (501.95 ± 27.59) μg · cm-2, and the mean infiltration rate was (42.25 ± 7.39) μg · cm-2 · h-1. Conclusion Edaravone gel has better percutaneous permeability and is expected to become a new drug delivery agent.