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【目的】探讨新生儿胎粪吸入综合征(meconium aspiration syndrome,MAS)伴有危重并发症的临床治疗。【方法】对浙江县人民医院2003年2月—2008年8月收治的76例MAS的患儿治疗作回顾性分析及探讨,所有病例均采用了综合治疗。【结果】76例MAS的患儿中有10例并发肺气肿(13.1%),肺不张4例(5.2%),急性呼吸窘迫综合征4例(5.2%),持续肺动脉高压6例(10.5%),肺出血4例(7.8%),其中有21例患儿出现了1～3种危重并发症,经综合治疗后治愈49例,好转12例,死亡15例,其治疗有效率为80.2%,死亡率为19.7%。【结论】MAS病死率较高,其危重并发症是MAS患儿死亡的主要原因。早期诊断和治疗,对降低其死亡率有重要意义。
【Objective】 To investigate the clinical treatment of neonatal meconium aspiration syndrome (MAS) associated with critical complications. 【Methods】 A retrospective analysis and discussion were made on the treatment of 76 children with MAS treated in Zhejiang People’s Hospital from February 2003 to August 2008, all the cases were treated with comprehensive treatment. 【Results】 Of the 76 children with MAS, 10 had pulmonary emphysema (13.1%), 4 (5.2%) had atelectasis, 4 (5.2%) had acute respiratory distress syndrome, 6 had persistent pulmonary hypertension 10.5%), 4 cases of pulmonary hemorrhage (7.8%), of which 21 cases of children with 1 to 3 kinds of critical complications, after treatment of 49 cases were cured, improved in 12 cases, 15 cases of death, the treatment efficiency 80.2%, the mortality rate was 19.7%. 【Conclusion】 The mortality rate of MAS is high, and the critical complication of MAS is the main cause of death in MAS. Early diagnosis and treatment, to reduce their mortality is of great significance.