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目的探讨原发性干燥综合征周围神经病变的发生与干燥综合征A型/B型抗体(抗SSA/SSB抗体)的关系。方法纳入2009年1月-2011年12月期间门诊及住院收治的原发性干燥综合征患者88例。所有患者均接受神经系统检查,采用蛋白质印迹法检测抗SSA抗体和抗SSB抗体,利用全自动化学发光仪检测血清维生素B12水平。结果 88例原发性干燥综合征患者中有27例(30.7%)存在周围神经病变。有或无周围神经病变的患者在年龄、性别、病程等一般情况方面无明显不同。有周围神经病变和无周围神经病变的原发性干燥综合征患者抗SSA抗体阳性率分别为70.4%(19/27)、70.5%(43/61),差异无统计学意义(χ2=0.000,P=0.991);抗SSA/SSB抗体双阳性率分别为63.0%(17/27)、14.8%(9/61),差异有统计学意义(χ2=17.416,P=0.000);血清维生素B12水平分别为(390±55)、(410±86)pg/dL,差异无统计学意义(t=0.908,P=0.370)。结论周围神经病变在原发性干燥综合征患者中较常见,且周围神经病变的发生多伴随血清抗SSA/SSB抗体阳性。
Objective To investigate the relationship between the occurrence of peripheral neuropathies in Sjogren’s syndrome and type A / B anti-SSA / SSB antibodies. Methods A total of 88 patients with primary Sjogren’s syndrome who were admitted to hospital and hospital from January 2009 to December 2011 were enrolled. All patients underwent neurological examinations. Western blotting was used to detect anti-SSA and anti-SSB antibodies. Serum vitamin B12 levels were measured using a fully automated chemiluminescence instrument. Results There were peripheral neuropathies in 27 of 88 patients (30.7%) with Sjogren’s syndrome. Patients with or without peripheral neuropathy did not differ significantly in general in terms of age, gender, duration of illness, and the like. The positive rates of anti-SSA antibodies in patients with primary Sjogren’s syndrome who had peripheral neuropathy and no peripheral neuropathy were 70.4% (19/27) and 70.5% (43/61), respectively, with no significant difference (χ2 = 0.000, P = 0.991). The positive rates of anti-SSA / SSB antibodies were 63.0% (17/27) and 14.8% (9/61) respectively, with significant difference (χ2 = 17.416, P = 0.000) (390 ± 55) and (410 ± 86) pg / dL, respectively. The difference was not statistically significant (t = 0.908, P = 0.370). Conclusion Peripheral neuropathy is more common in patients with primary Sjogren’s syndrome, and the occurrence of peripheral neuropathy is more associated with the presence of anti-SSA / SSB antibodies in serum.