以2-[(1,3,4-噻二唑基-2-氨基)甲基]苯酚和CH2Cl2为原料,首次采用相转移催化法合成了一系列新型3-(1,3,4-噻二唑基)-1,3-苯并噁嗪类化合物,产率为47%～62%.研究了相转移催化剂的用量、反应物用量、反应温度等对反应产率的影响.产物结构用IR,1H NMR,13C NMR和元素分析进行了表征.初步研究了目标化合物的杀菌活性,大部分化合物具有一定的杀菌活性. A series of novel 3- (1,3,4-thiadiazolyl-2-amino) methyl] phenol and CH2Cl2 were synthesized by phase transfer catalysis using 2 - [(1,3,4- Oxadiazolyl) -1,3-benzoxazin was obtained in 47% -62% yield.The effects of the amount of the phase transfer catalyst, the amount of reactants and the reaction temperature on the reaction yield were investigated. IR, 1H NMR, 13C NMR and elemental analysis. The bactericidal activity of the target compounds was studied preliminarily. Most of the compounds showed some bactericidal activity.