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目的研究HLA_DQB1等位基因多态性与肝硬化的遗传易感性,为寻找肝硬化的易感基因或抗病基因提供线索。方法应用PCR_SSP技术检测106例湖北汉人乙肝后肝硬化患者和108例正常人HLA_DQB1等位基因,并结合临床资料进行比较分析。结果肝硬化组DQB10501等位基因频率明显升高(24.52%vs11.11%,RR=2.6,P<0.01),DQB10602等位基因频率明显下降(4.7%vs12.03%,RR=0.3618,P<0.05),其他等位基因频率在两组之间无显著性差异。提示DQB10501等位基因与湖北地区汉人乙肝后肝硬化关联,DQB10602等位基因则呈负关联。结论DQB10501等位基因可能是湖北地区汉族人乙肝后肝硬化的易感基因,DQB10602则为抵抗基因。
Objective To investigate the genetic predisposition of HLA-DQB1 alleles and cirrhosis and to provide clues for the search of susceptible genes or resistance genes in cirrhosis. Methods PCR_SSP technique was used to detect HLA-DQB1 alleles in 106 Han patients with hepatitis B cirrhosis and 108 normal controls in Hubei province. The alleles were compared with clinical data. Results The frequency of DQB10501 allele was significantly higher in cirrhotic patients (24.52% vs11.11%, RR = 2.6, P <0.01), and the frequency of DQB10602 allele was significantly decreased (4.7% vs12.03%, RR = 0.3618, P < 0.05), other allele frequency in the two groups no significant difference. These results suggest that allele DQB10501 is associated with posthepatitic cirrhosis in Han Chinese in Hubei Province, while allele DQB10602 is negatively correlated. Conclusion The allele DQB10501 may be a susceptible gene for posthepatitic cirrhosis in Han nationality in Hubei Province, while DQB10602 is a resistance gene.