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为了探讨乳腺癌患者化疗时凝血参数的动态变化及临床意义,检测100例乳腺癌经手术患者化疗前后的凝血酶原时间(PT)、活化的部分凝血活酶时间(APTT)、纤维蛋白原含量(FIB)、凝血酶时间(TT),并与100例健康体检者和良性肿瘤患者进行对比分析。观察患者化疗前后凝血指标的变化,比较组间和组内的差异。乳腺癌患者化疗前与对照组比较,PT、APTT和TT差异均无统计学意义(P>0.05),而FIB含量明显高于对照组,P<0.05。乳腺癌患者在化疗过程中PT和APTT无明显变化,与化疗前比较差异无统计学意义,P>0.05;而FIB含量化疗后比化疗前逐渐升高,差异有统计学意义,P<0.05。TT化疗后与化疗前对比逐渐缩短,差异有统计学意义,P<0.05。乳腺癌患者凝血指标的定期监测可能是判断乳腺癌预后以及化疗后复发和转移的有价值指标。
To investigate the dynamic changes and clinical significance of coagulation parameters in patients with breast cancer during chemotherapy, the prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen content (FIB) and thrombin time (TT), and compared with 100 healthy subjects and benign tumor patients. Changes of coagulation index in patients before and after chemotherapy were observed, and the differences between groups were compared. There was no significant difference in PT, APTT and TT between breast cancer patients and control group before chemotherapy (P> 0.05), but FIB content was significantly higher than that of control group (P <0.05). There was no significant difference in PT and APTT between the patients with breast cancer and before chemotherapy, P> 0.05; however, the FIB content increased gradually after chemotherapy compared with that before chemotherapy, with statistical significance (P <0.05). After chemotherapy, the contrast between chemotherapy and chemotherapy was gradually shortened, the difference was statistically significant (P <0.05). Periodic monitoring of coagulation markers in breast cancer patients may be a valuable indicator of breast cancer prognosis and recurrence and metastasis after chemotherapy.